Gene information
Official symbol CX3CL1
Official full name C-X3-C motif chemokine ligand 1
Gene type protein-coding gene
Chromosome16q21
Alias symbolNTN; C3Xkine; ABCD-3; CXC3C; CXC3
Previous symbolSCYD1
Gene familyChemokine ligands
Resources
Entrez Gene 6376
HGNC HGNC:10647
Ensembl ENSG00000006210
Vega OTTHUMG00000133469
UCSC uc002eli.4
GO terms: 196 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001774 microglial cell activation GO Biological Processes -13.1367436 11 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0001952 regulation of cell-matrix adhesion GO Biological Processes -7.29794194 21 More
GO:0002052 positive regulation of neuroblast proliferation GO Biological Processes -5.41672963 8 More
GO:0002269 leukocyte activation involved in inflammatory response GO Biological Processes -12.6026553 11 More
GO:0002274 myeloid leukocyte activation GO Biological Processes -20.6988408 25 More
GO:0002523 leukocyte migration involved in inflammatory response GO Biological Processes -8.96527714 10 More
GO:0002548 monocyte chemotaxis GO Biological Processes -10.9439631 11 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002931 response to ischemia GO Biological Processes -6.57469730 13 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0008009 chemokine activity GO Molecular Functions -11.8970416 12 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010812 negative regulation of cell-substrate adhesion GO Biological Processes -8.89322529 17 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0010976 positive regulation of neuron projection development GO Biological Processes -4.13061709 18 More
GO:0014009 glial cell proliferation GO Biological Processes -5.99718380 5 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0021700 developmental maturation GO Biological Processes -12.5205714 23 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032231 regulation of actin filament bundle assembly GO Biological Processes -4.42971140 15 More
GO:0032233 positive regulation of actin filament bundle assembly GO Biological Processes -4.83092272 7 More
GO:0032650 regulation of interleukin-1 alpha production GO Biological Processes -5.67855223 6 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032691 negative regulation of interleukin-1 beta production GO Biological Processes -9.98402343 15 More
GO:0032692 negative regulation of interleukin-1 production GO Biological Processes -11.9554195 18 More
GO:0032720 negative regulation of tumor necrosis factor production GO Biological Processes -18.6356508 28 More
GO:0032908 regulation of transforming growth factor beta1 production GO Biological Processes -3.34912948 3 More
GO:0032914 positive regulation of transforming growth factor beta1 production GO Biological Processes -4.12631862 3 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0033622 integrin activation GO Biological Processes -5.24494293 4 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0034341 response to interferon-gamma GO Biological Processes -10.8524889 26 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042116 macrophage activation GO Biological Processes -15.3664951 15 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042379 chemokine receptor binding GO Molecular Functions -11.1027858 13 More
GO:0042551 neuron maturation GO Biological Processes -3.82142288 8 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043030 regulation of macrophage activation GO Biological Processes -14.6396218 15 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0045123 cellular extravasation GO Biological Processes -12.7826256 12 More
GO:0045236 CXCR chemokine receptor binding GO Molecular Functions -7.10577702 6 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048167 regulation of synaptic plasticity GO Biological Processes -4.27696718 22 More
GO:0048247 lymphocyte chemotaxis GO Biological Processes -6.64704408 8 More
GO:0048469 cell maturation GO Biological Processes -5.75704415 12 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051279 regulation of release of sequestered calcium ion into cytosol GO Biological Processes -5.25087734 14 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051495 positive regulation of cytoskeleton organization GO Biological Processes -3.67944181 20 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0061517 macrophage proliferation GO Biological Processes -6.00954872 4 More
GO:0061518 microglial cell proliferation GO Biological Processes -6.00954872 4 More
GO:0061900 glial cell activation GO Biological Processes -13.6981492 12 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0070661 leukocyte proliferation GO Biological Processes -8.25401122 12 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071346 cellular response to interferon-gamma GO Biological Processes -8.94844866 13 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071634 regulation of transforming growth factor beta production GO Biological Processes -6.40741477 11 More
GO:0071636 positive regulation of transforming growth factor beta production GO Biological Processes -3.83961894 4 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071695 anatomical structure maturation GO Biological Processes -11.1692541 20 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0110053 regulation of actin filament organization GO Biological Processes -3.93783734 26 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:0150076 neuroinflammatory response GO Biological Processes -13.2187099 12 More
GO:0150077 regulation of neuroinflammatory response GO Biological Processes -14.4671881 13 More
GO:0150079 negative regulation of neuroinflammatory response GO Biological Processes -5.31723275 7 More
GO:1901099 negative regulation of signal transduction in absence of ligand GO Biological Processes -4.18352224 5 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1902692 regulation of neuroblast proliferation GO Biological Processes -5.09447312 9 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902905 positive regulation of supramolecular fiber organization GO Biological Processes -5.32876142 22 More
GO:1903169 regulation of calcium ion transmembrane transport GO Biological Processes -8.80532519 28 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -18.2876323 28 More
GO:1903975 regulation of glial cell migration GO Biological Processes -5.72938190 7 More
GO:1903977 positive regulation of glial cell migration GO Biological Processes -7.18867136 7 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904427 positive regulation of calcium ion transmembrane transport GO Biological Processes -4.11465146 13 More
GO:1905521 regulation of macrophage migration GO Biological Processes -12.9236434 12 More
GO:1905523 positive regulation of macrophage migration GO Biological Processes -10.7598894 9 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000177 regulation of neural precursor cell proliferation GO Biological Processes -5.62902185 15 More
GO:2000179 positive regulation of neural precursor cell proliferation GO Biological Processes -3.60984508 9 More
GO:2001222 regulation of neuron migration GO Biological Processes -2.05696162 6 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO Biological Processes -4.65044629 6 More
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO Biological Processes -4.18352224 5 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
atezolizumab CIViC 25428504 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
fractalkine proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Xu B et al. Cytokine. 2019
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